Minoxidil Slows or halts hair loss and promotes hair regrowth in both men and women. Topical: applied to the scalp as a liquid or foam, Minoxidil is offered in 2% and 5% concentrations. The 5% concentration was developed for treatment of male-pattern hair loss, but studies have shown that women also can benefit from the 5% formula. Positive response to minoxidil therapy (reduced hair loss and/or hair regrowth) has been noted in from less to 50% to more than 80% of persons treated in various studies.
Positive response is lost if minoxidil therapy is discontinued. Minoxidil needs to be applied once or the recommended twice daily, and may be used indefinitely for continued support of existing hair follicles and the maintenance of any experienced hair re-growth. To achieve maximum effect, the solution should be in contact with the scalp for at least 4 hours before allowing hair to get wet.
The mechanism by which minoxidil promotes hair growth is not fully understood. Minoxidil is a vasodilator & is used as an oral drug to decrease Blood pressure. as an oral drug to decrease Blood pressure. Technically speaking, if the blood vessels are widened and potassium channels are opened, then it will allow more oxygen, blood and nutrients to the focille. This will cause focilles in the telogen phase to shed, which are replaced by a new anagen phase which is basically thicker hair.
Minoxidil is generally well tolerated, Adverse effects of minoxidil include burning or irritation of the eye, itching, redness at the treated area. Accidental application can result in unwanted hair growth on Face.
Finasteride is the only oral medicine which is US FDA approved for treatment of Male Pattern Baldness. Finasteride has been found to have long-term effectiveness and safety in treating MPB in men of all ages and all ethnic backgrounds. It has been used for Hair fall treatment since more than 10 years. Finasteride is used alone or in combination with Minoxidil for Hair fall Treatment. Finasteride’s effects in slowing hair loss and stimulating new hair growth work in majority of men. Finasteride is most effective in stimulating hair regrowth over the crown of the scalp. It is less effective in stimulating regrowth at the front of the scalp-where hair loss is commonly called a “receding hairline”.
Finasteride selectively inhibits the activity of enzyme 5-alpha-reductase that converts the “male hormone” testosterone into dihydro testosterone (DHT ) a form that is active in hair follicles. DHT is believed to act on scalp hair follicles to render them inactive and incapable of producing full-grown hair. Inhibition of Type II 5-alpha-reductase results in lower levels of DHT in hair follicles and prostate tissue and decrease the likelihood for development of MPB and benign prostate enlargement.
Finasteride was first developed more than 20 years ago to treat benign prostate enlargement. Finastride. at a dose of 5 milligrams a day is used in treatment of benign prostate enlargement in men. Following the lead of finasteride’s effectiveness in treating benign prostate enlargement, investigators studied its use in treating MPB. These studies confirmed that at a dose of 1 milligram per day, Finasteride is safe & effective in treating MPB in majority but not all men.
Reported Adverse effects include decreased libido (sex drive), erectile dysfunction, male breast enlargement and psychological depression. Finasteride is not approved the use in women, and particularly in women who are pregnant or who become pregnant.
The drug has potential for interfering with sexual development of a fetus.
In 1992, finasteride (5 mg) was approved by the U.S. Food and Drug Administration (FDA) for treatment of benign prostatic hyperplasia (BPH).
In 1997, FDA gave approval for a second indication of finasteride (1 mg) for treatment of Male pattern Baldness (MPB)